The TAL1/SCL LS-C182473 Conjugated Antibody from MyBioSource.com is a Mouse Monoclonal antibody to TAL1. This antibody recognizes Human, Mouse, and Rat antigen. The TAL1/SCL LS-C182473 Conjugated Antibody has been validated for the following applications: Other.
Description
Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic coexpression of TAL1 and the catalytic subunit of casein kinase IIalpha, a serine/ threonine protein kinase known to modulate the activity of other beta HLH transcription factors